Population
Primary cultures of mouse renal juxtaglomerular (JG) cells
Design
Preclinical
Follow-up
21 hours
Authors
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Caution against clinical extrapolation from mouse JG cells; extends NO-renin duality but leaves mechanisms open for in vivo study.
Nitric oxide liberators exert a dual effect on renin secretion in isolated mouse JG cells, with initial inhibition via soluble guanylate cyclase and subsequent stimulation requiring extracellular calcium.
Schricker et al. (1993) studied this question.
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