July 5, 2006AJP Renal Physiology

Regulation of renin in mice with Cre recombinase-mediated deletion of G protein Gsα in juxtaglomerular cells

View Full Paper

Ask AI

Bookmark

Population

Mice with Cre recombinase-mediated deletion of G protein Gsα in juxtaglomerular cells

Comparison

Conditional Gsalpha deficiency in… vs Wild-type animals

Design

Preclinical

Authors

LCLimeng ChenDian Diagnostics (China)SKSoo Mi KimChonbuk National University Hospital MOMona OppermannUniversity Hospital Regensburg

Discussion

Member takes

Implication

Gsα is essential for renin control in mice; leaves open its viability as a human therapeutic target.

Structured PICO

Population

Mice with Cre recombinase-mediated deletion of G protein Gsα in juxtaglomerular cells (generated by crossing mice with Cre under endogenous renin promoter and mice with floxed Gnas exon 1)

Intervention

Conditional Gsalpha deficiency in juxtaglomerular granular (JG) cells

Comparator

Wild-type animals

Outcome

Basal levels of renin expression and plasma renin concentrationssurrogate

Gsalpha-mediated signal transduction is essential and nonredundant in the control of renin synthesis and release.

Cite This Study

Chen et al. (2006) studied this question.

synapsesocial.com/papers/6a86ace7a6ddb97d43d3b2e4 https://doi.org/10.1152/ajprenal.00193.2006

View Full Paper

Ask AI

Bookmark

Regulation of renin in mice with Cre recombinase-mediated deletion of G protein Gsα in juxtaglomerular cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regulation of renin in mice with Cre recombinase-mediated deletion of G protein Gsα in juxtaglomerular cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider