Why the study?
Does breathing 50% nitrous oxide in oxygen alter cerebral autoregulation in healthy volunteers?
Population
n=9 healthy human volunteers
Comparison
Breathing 100% oxygen or 50% nitrous oxide in… vs Breathing room air
Design
Other
Follow-up
Acute (10 minutes after achieving target gas fractions)
Authors
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Nitrous oxide may impair cerebral autoregulation; hypothesis-generating in volunteers and should not yet change anesthesia practice.
Does breathing 50% nitrous oxide in oxygen alter cerebral autoregulation in healthy volunteers?
Breathing 50% nitrous oxide in oxygen significantly increases middle cerebral artery blood flow velocity and impairs cerebral autoregulation in healthy volunteers.
Girling et al. (1999) studied this question.
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