Why the study?
Does the endothelin A receptor antagonist LU 135252 prevent progressive renal dysfunction and mortality in uninephrectomized stroke-prone spontaneously hypertensive rats?
Does the endothelin A receptor antagonist LU 135252 prevent progressive renal dysfunction and mortality in uninephrectomized stroke-prone spontaneously hypertensive rats?
The ETA receptor antagonist LU 135252 completely prevents mortality and progressive renal injury in a salt-loaded hypertensive rat model.
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Supports ETA antagonism in hypertensive renal models; leaves open translation to human therapy.
Orth et al. (1998) studied this question.
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