The contribution of tumour necrosis factor‐α and endothelin‐1 to the increase of coronary resistance in hearts from rats treated with endotoxin
Why the study?
Does inhibition of TNF-alpha or ETA receptors prevent LPS-induced increases in coronary vascular resistance in a rat model of circulatory shock?
Population
Anaesthetized rats
Comparison
Lipopolysaccharide 10 mg kg-1 i.v., with or… vs Control rats
Design
Preclinical
Follow-up
Up to 180 minutes post-injection
Authors
Discussion
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Member takes
Implication
TNF-α/ETA blockade may attenuate coronary vasoconstriction in rat endotoxemia; hypothesis-generating and untested in human shock.
Structured PICO
Does inhibition of TNF-alpha or ETA receptors prevent LPS-induced increases in coronary vascular resistance in a rat model of circulatory shock?
P
Population
Anaesthetized rats
I
Intervention
Lipopolysaccharide (LPS) 10 mg kg-1 i.v., with or without pre-treatment with cycloheximide, anti-TNF-alpha antibody, or endothelin ETA receptor selective antagonist FR 139317
C
Comparator
Control rats
O
Outcome
Coronary perfusion pressure/vascular resistance in isolated Langendorff perfused heartssurrogate
In a rat model of LPS-induced shock, the sequential release of TNF-alpha and endothelin-1 mediates an increase in coronary vascular tone, which can be attenuated by TNF-alpha or ETA receptor blockade.
Cite This Study
Hohlfeld et al. (1995) studied this question.