Altered Peripheral Vascular Responses to Exogenous and Endogenous Endothelin–1 in Patients With Well–Compensated Cirrhosis
Why the study?
Do peripheral vascular responses to exogenous and endogenous endothelin-1 differ in patients with well-compensated cirrhosis compared to healthy controls?
Population
11 patients with well-compensated cirrhosis and 8 matched healthy controls
Comparison
Unilateral, subsystemic, intrabrachial artery… vs Matched healthy controls receiving the same…
Design
Case-control
Authors
Discussion
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Member takes
Implication
Altered ET-1 responses may indicate heightened ET(A) tone in compensated cirrhosis; hypothesis-generating for targeted receptor blockade.
Structured PICO
Do peripheral vascular responses to exogenous and endogenous endothelin-1 differ in patients with well-compensated cirrhosis compared to healthy controls?
P
Population
11 patients with well-compensated cirrhosis and 8 matched healthy controls
I
Intervention
Unilateral, subsystemic, intrabrachial artery infusions of endothelin-1 (ET-1) (2 and 6 pmol/min), BQ-123 (3 and 10 nmol/min), and BQ-788 (0.3 and 1 nmol/min)
C
Comparator
Matched healthy controls receiving the same infusions
O
Outcome
Forearm blood flow (FBF) measured by venous occlusion plethysmographysurrogate
Patients with well-compensated cirrhosis exhibit altered peripheral vascular responses to endothelin-1, suggesting a greater contribution of ET-1 to maintaining basal vascular tone via the ET(A) receptor.
Cite This Study
Helmy et al. (2001) studied this question.