What question did this study set out to answer?

To determine the long-term impact of parathyroidectomy versus observation on fat mass and markers of glucose and lipid metabolism in mild primary hyperparathyroidism.

July 16, 2018Endocrine ConnectionsOpen Access

The effect of surgery on fat mass, lipid and glucose metabolism in mild primary hyperparathyroidism

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Authors

KGKristin GodangOslo University Hospital KLKarolina LundstamSahlgrenska University Hospital CMCharlotte MollerupCopenhagen University Hospital

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Implication

Randomized trial reveals parathyroidectomy does not improve metabolic or cardiovascular risk markers in mild primary hyperparathyroidism, suggesting observation is a safe strategy.

Key Points

To determine the long-term impact of parathyroidectomy versus observation on fat mass and markers of glucose and lipid metabolism in mild primary hyperparathyroidism.
Open randomized multicenter trial (Scandinavian Investigation of Primary Hyperparathyroidism) analyzing 119 patients assigned to observation (OBS; n = 58) or parathyroidectomy (PTX; n = 61).
Evaluated fat mass, glucose metabolism parameters, and lipid profiles over a 5-year follow-up period.
Total cholesterol decreased in the OBS group from 5.9 ± 1.1 to 5.6 ± 1.0 mmol/L (P = 0.037) and LDL cholesterol decreased from 3.7 ± 1.0 to 3.3 ± 0.9 mmol/L (P = 0.010), while remaining unchanged in the PTX group, resulting in significant between-group differences over time (P = 0.013 and P = 0.026, respectively) driven by more OBS patients starting lipid-lowering drugs (5 vs. 1).
No significant between-group differences emerged over time for trunk fat mass or glucose metabolism markers, though 25(OH) vitamin D increased significantly in the PTX group (P < 0.001) but not in the OBS group.

Cite This Study

Godang et al. (2018) studied this question.

synapsesocial.com/papers/6a86b2e458c65cf508d3b148 https://doi.org/10.1530/ec-18-0259

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Implication

Randomized trial reveals parathyroidectomy does not improve metabolic or cardiovascular risk markers in mild primary hyperparathyroidism, suggesting observation is a safe strategy.

The effect of surgery on fat mass, lipid and glucose metabolism in mild primary hyperparathyroidism

Discussion

Member takes

Implication

Key Points

Cite This Study

The effect of surgery on fat mass, lipid and glucose metabolism in mild primary hyperparathyroidism

Discussion

Member takes

Implication

Key Points

Cite This Study

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