Key result
Parathyroidectomy significantly reduced left ventricular mass in patients with primary hyperparathyroidism (Hedges g -0.250; 95% CI -0.450 to -0.050), with greater improvements in shorter-term studies.
Why the study?
Does parathyroidectomy reduce left ventricular mass in patients with primary hyperparathyroidism?
Population
15 studies pooling 457 participants with primary hyperparathyroidism who had left ventricular mass measured…
Comparison
Parathyroidectomy (PTX) vs Observation or baseline (pre-PTX)
Design
Meta-analysis
Authors
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Supports parathyroidectomy for LV mass reduction in primary hyperparathyroidism; confirms benefit via meta-analysis.
Meta-Analysis (n=457)
Does parathyroidectomy reduce left ventricular mass in patients with primary hyperparathyroidism?
Standardized Mean Difference: -0.25 (95% CI -0.45–-0.05)
Parathyroidectomy reduces left ventricular mass in patients with primary hyperparathyroidism, particularly in the short term and in those with higher preoperative PTH levels.
McMahon et al. (2015) conducted a meta-analysis in Primary hyperparathyroidism (PHPT) (n=457). Parathyroidectomy (PTX) vs. Observation or baseline was evaluated on Left ventricular mass (LVM) (Hedges g -0.250, 95% CI -0.450 to -0.050). Parathyroidectomy significantly reduced left ventricular mass in patients with primary hyperparathyroidism (Hedges g -0.250; 95% CI -0.450 to -0.050), with greater improvements in shorter-term studies.
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