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Experimental study demonstrates time-lapse monitoring of pH decrease during receptor internalization in living cells, suggesting utility for tracking protein endocytosis.
Fluorescence imaging of the local pH environment surrounding proteins offers an understanding of cellular processes, including receptor endocytosis. We herein develop a pH-responsive fluorescent β-lactamase inhibitor for protein labeling via a genetically encodable β-lactamase tag. Our probe enabled time-lapse monitoring of pH decrease during internalization of membrane receptor proteins in living cells.
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Li et al. (2026) studied this question.
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