What question did this study set out to answer?

To review human induced pluripotent stem cell-derived models of microglia and astrocytes used to investigate neuroimmune mechanisms, genetic risk factors, and pathologies in Alzheimer's disease.

August 20, 2026International Journal of Molecular SciencesOpen Access

Human Stem Cell-Derived Models of the Alzheimer’s Disease Neuroimmune System

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Authors

RSRose A. Summers DQDaphne QuangUniversity of Colorado Anschutz Medical Campus NJNoah R. JohnsonBrigham Young University

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Implication

Review uncovers stem cell-derived neuroimmune platforms for Alzheimer's disease, highlighting how microglia and astrocyte models enable genetic and therapeutic investigations.

Key Points

To review human induced pluripotent stem cell-derived models of microglia and astrocytes used to investigate neuroimmune mechanisms, genetic risk factors, and pathologies in Alzheimer's disease.
Synthesized literature on 2D monocultures, co-cultures, 3D organoids, assembloids, and chimeric systems generated from human induced pluripotent stem cells (hiPSCs).
Assessed studies evaluating familial mutations (APP, PSEN1, PSEN2), sporadic risk variants (APOE, TREM2), and trisomy 21 in neuroimmune contexts.
hiPSC-derived neuroimmune platforms reproduce human-specific cellular behaviors, including neuroinflammation, protein aggregate propagation, and amyloid-beta clearance.
Emerging 3D organoid, assembloid, and chimeric models provide enhanced physiological relevance for live-imaging pathology and high-throughput drug screening.

Cite This Study

Summers et al. (2026) studied this question.

synapsesocial.com/papers/6a86b5978a91293e6a1cd09e https://doi.org/10.3390/ijms27167360

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Implication

Review uncovers stem cell-derived neuroimmune platforms for Alzheimer's disease, highlighting how microglia and astrocyte models enable genetic and therapeutic investigations.

Human Stem Cell-Derived Models of the Alzheimer’s Disease Neuroimmune System

Discussion

Member takes

Implication

Key Points

Cite This Study

Human Stem Cell-Derived Models of the Alzheimer’s Disease Neuroimmune System

Discussion

Member takes

Implication

Key Points

Cite This Study

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