What question did this study set out to answer?

To determine the molecular basis, clinical characteristics, and functional consequences of inherited platelet GPIV (CD36) deficiency in patients presenting with bleeding symptoms.

August 20, 2026BiomoleculesOpen Access

Inherited Platelet GPIV Deficiency: First Description of a Series of Unrelated Patients with Bleeding Diathesis

View Full Paper

Ask AI

Bookmark

To determine the molecular basis, clinical characteristics, and functional consequences of inherited platelet GPIV (CD36) deficiency in patients presenting with bleeding symptoms.
Characterized clinical history, CD36 gene variants, platelet GPIV expression levels, and von Willebrand factor levels in four unrelated patients (N=4) presenting with lifelong bleeding diathesis.
Evaluated platelet function using light-transmission aggregometry, granule secretion assays, and high-shear flow adhesion to type I collagen.
Heterozygous CD36 variants were associated with markedly reduced platelet GPIV expression and impaired platelet adhesion to type I collagen under high-shear flow conditions.
Patients demonstrated normal light-transmission aggregometry and normal platelet granule content and release, while three of the four patients displayed slightly reduced von Willebrand factor levels.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Case series reveals bleeding diathesis and impaired collagen adhesion in patients with heterozygous CD36 variants, suggesting GPIV testing belongs in platelet disorder workups.

Cite This Study

Bury et al. (2026) studied this question.

synapsesocial.com/papers/6a86b5b08a91293e6a1cd2e8 https://doi.org/10.3390/biom16081205

View Full Paper

Ask AI

Bookmark

Implication

Case series reveals bleeding diathesis and impaired collagen adhesion in patients with heterozygous CD36 variants, suggesting GPIV testing belongs in platelet disorder workups.

Inherited Platelet GPIV Deficiency: First Description of a Series of Unrelated Patients with Bleeding Diathesis

Key Points

Discussion

Implication

Cite This Study

Inherited Platelet GPIV Deficiency: First Description of a Series of Unrelated Patients with Bleeding Diathesis

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider