⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

August 17, 2026Transfusion

A novel RHD variant allele harboring c.487‐ 14G >A in trans to an RHD ‐null allele associated with reduced RHD expression

Xi Yuan Qunjuan Zeng Jia Zhang Xin Jiao Yulin Qian

View at Publisher

Ask AI

Bookmark

Share

Key Points

To identify and describe a novel RHD gene variant and characterize its impact on RHD expression.
Sequenced and analyzed the RHD gene locus to detect novel nucleotide variants.
Submitted and annotated the NM_016124.6(RHD):c.487-14G>A sequence variant in the GenBank database under accession number PQ801658.1.
Identified a novel RHD variant allele carrying the intronic mutation c.487-14G>A.
Demonstrated that this variant occurs in trans to an RHD-null allele and is associated with reduced RHD expression.

No abstract yet

We only have this paper's title and publication details.

Read it at the source→

Implication

Genetic analysis identifies a novel RHD variant harboring c.487-14G>A in trans with an RHD-null allele, revealing reduced RHD antigen expression.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Yuan et al. (2026) studied this question.

synapsesocial.com/papers/6a86b5da8a91293e6a1cd56d https://doi.org/10.1111/trf.70370

View at Publisher

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1A novel <scp><i>RHD</i></scp> allele caused by c.767 C>T mutation was identified in a Chinese individual2024 · 2 citations
2A novel <scp> <i>RHD</i> </scp> allele (c.727 T>G) associated with reduced D antigen expression in a pregnant Chinese womanOriginal Research · 2026
3The c.<scp>254C</scp>>A change (p.<scp>Ala85Glu</scp>) in <i>RHD</i> causing a weak D phenotype2024
4A novel <i>RHD*01N</i> allele harboring a c.634+<scp>1G</scp>>A splice site variant results in the <scp>RhD</scp>‐negative phenotype in a Chinese blood donor2025 · 1 citations
5Novel <i>RHD</i> allele with c.487‐<scp>2A</scp>>G (<scp>IVS3</scp>‐<scp>2A</scp>>G) variant causing <scp>RhD</scp> negative phenotype2024

More related papers

Two novel variant allele of the <scp>RHD</scp> gene detected in two Chinese blood donors with the <scp>RHD</scp> negative phenotype2025
A novel <i>RHD</i> allele caused by the <i>RHD IVS4</i> + <i>2delT</i> mutation identified in a Chinese Han male donor with a D‐negative phenotype2026
Identification of a novel A allele with a c. <scp>610G</scp> >A variation on the <i>ABO*A1.02</i> allele2026

More from Transfusion

Quality improvement program for transfusion reaction reporting and managementSun,
A novel RHCE*01.48 allele associated with weak clone‐dependent E‐like reactivity: Serologic, molecular, and computational analysisSat,