Key result
Lower circadian rest-activity rhythm amplitude is linked to ~30% higher risk of appropriate ICD therapy.
Why the study?
Prediction of future ventricular arrhythmias requiring ICD therapy remains challenging and the predictive value of circadian rest-activity rhythm disruption in ICD patients is unclear.
Does circadian rest-activity rhythm disruption predict appropriate ICD therapy for ventricular arrhythmias in patients with an ICD?
Observational (n=274)
Yes
Does circadian rest-activity rhythm disruption predict appropriate ICD therapy for ventricular arrhythmias in patients with an ICD?
Answers are grounded in this paper and cite their sources.
Wearable-derived circadian rest-activity rhythm disruption, specifically lower relative amplitude and increasing intradaily variability, independently predicts malignant ventricular arrhythmias requiring ICD therapy.
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Raijmakers et al. (2026) conducted an observational in Patients with an implantable cardioverter-defibrillator (ICD) or cardiac resynchronization therapy defibrillator (n=274). Lower circadian rest-activity rhythm (CRAR) relative amplitude vs. Higher CRAR relative amplitude was evaluated on Appropriate ICD therapy (shock and/or ATP) for VF or sustained VT during 12 months of follow-up (HR 0.77, 95% CI 0.62-0.96). Each 0.1-unit decrease in circadian rest-activity rhythm relative amplitude was associated with a 30% higher risk of appropriate ICD therapy.
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