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August 20, 2026MicroorganismsOpen Access

Temporal Trends in Pathogens and Clinical Outcomes of Adult Deep Neck Infections: An 18-Year Multicenter Cohort Study of 12,063 Cases

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Authors

FLFang‐Ching LiuALAng LuPYPei‐Rung Yang

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Overview

Retrospective cohort study reveals shifting bacterial profiles and declining mortality in deep neck infections, highlighting the need for broader empiric antimicrobial regimens.

Key Points

  • To investigate 18-year temporal trends in bacterial pathogens, management strategies, and clinical outcomes among adult patients hospitalized with deep neck infections.
  • Retrospective multicenter cohort study analyzing 12,063 hospitalized adult patients (aged ≥18 years) with deep neck infections in Taiwan between 2006 and 2023.
  • Patients were stratified into two 9-year periods: Epoch 1 (2006–2014, n = 5,512) and Epoch 2 (2015–2023, n = 6,551) using the Chang Gung Research Database.
  • Assessed demographic variables, comorbidities, surgical vs. medical interventions, microbiological cultures (aerobes and anaerobes), and in-hospital complications.
  • In-hospital mortality decreased from 7.7% in Epoch 1 to 6.4% in Epoch 2, and descending necrotizing mediastinitis fell from 2.7% to 0.7%.
  • Antibiotic-only management increased from 77.3% to 83.2%, whereas surgical intervention rates declined from 22.7% to 16.9%.
  • Polymicrobial infections rose from 45.3% to 53.7%, with notable shifts toward Streptococcus anginosus group, Prevotella species, and Parvimonas micra.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a86b5ff8a91293e6a1cdad3https://doi.org/10.3390/microorganisms14081826
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Individualized multidisciplinary management of severe odontogenic deep neck infections with and without descending necrotizing mediastinitis: a report of two cases2026
  2. 2Global Burden of Deep Neck Space Abscesses: Epidemiology, Challenges, and Outcomes2026
  3. 3Recognizing Descending Necrotizing Mediastinitis in Adults: A Narrative Review of Diagnostic Dilemmas and Barriers2026
  4. 4Deep neck space infections among patients attending a tertiary Ugandan hospital: clinical presentation, bacterial etiology and antimicrobial susceptibility2024
  5. 5Clinicopathological Profile of Deep Neck Space Infections in a Rural Tertiary Care Center: A Prospective Study2026