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July 1, 1975Circulation ResearchOpen Access

Localization patterns of plasma apolipoproteins in human atherosclerotic lesions.

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Authors

HHHans HoffSigmund Freud Privatuniversität Wien CHCarol L. HeidemanHouston Methodist RJRichard L. JacksonAmerican Heart Association

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Implication

Histological study demonstrates specific co-retention of apolipoproteins and fibrinogen in human arterial plaques, indicating multi-lipoprotein involvement in atherosclerosis.

Key Points

To determine the localization patterns of plasma lipoproteins, their constituent apoproteins, and neutral lipids within normal and atherosclerotic human arterial tissue.
Applied immunofluorescence microscopy using specific antisera against apoB (LDL), apoA-I (HDL), and apoC-III (VLDL), alongside neutral lipid staining, to arterial specimens collected at surgery or autopsy.
Assessed the localization of control serum proteins, including fibrinogen and albumin, across fibrous plaques, fatty streaks, and uninvolved arterial segments.
Co-localization of all three apoproteins (apoB, apoA-I, apoC-III) and neutral lipid occurred within lipid cores and connective tissue in 61% of fibrous plaques and 48% of fatty streaks, whereas 0% of uninvolved arterial regions showed all four factors together.
Fibrinogen localized to regions of maximum factor accumulation in 37% of fibrous plaques and 64% of fatty streaks, while albumin localized to these areas in only 4% to 5% of cases.

Cite This Study

Hoff et al. (1975) studied this question.

synapsesocial.com/papers/6a86bfb6bb0787ff27ca05b9 https://doi.org/10.1161/01.res.37.1.72

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