Key result
Patients with coronary stenosis had significantly higher serum apolipoprotein B levels (121.5 vs 98.5 mg/dl, p<0.05) and lower HDL3 levels compared to those without stenosis.
Cross-Sectional (n=36)
Absolute Event Rate: 121.5% vs 98.5%
p-value: p=<0.05
Serum apolipoprotein B levels positively correlate with coronary stenosis severity, suggesting it is an atherogenic factor, while HDL3 may be antiatherogenic.
Higher ApoB and lower HDL3 associate with stenosis; cross-sectional data leaves open causal role and prospective validation.
The levels of serum apolipoproteins, lipoproteins and lipids in 36 patients undertaking coronary angiography were measured and their relations with the severity of coronary stenosis were evaluated.Also, correlation between variables of stenosis (+) group and those of stenosis (-) group were evaluated.There was a significant positive correlation between the severity of coronary stenosis and the serum level of apolipoprotein B (p<0.05).The serum apolipoprotein B was significantly higher in the stenosis (+) group (p<0.05).Apolipoprotein B/apolipoprotein A-II ratio in serum was also significantly higher in the stenosis (+) group (p<0.01).The serum HDL3 showed significantly lower level in the stenosis (+) group. From these findings apolipoprotein B may be an atherogenic factor and HDL3 may be a antiatherogenic factor. Moreover, there were significant positive correlations both between the serum HDL2 and apolipoprotein A-I and between the serum HDL3 and apolipoprotein A-II, suggesting that they would have some relations one another.
No takes yet. Share an insight, caveat, or question.
Ebihara et al. (1988) conducted a cross-sectional in Coronary atherosclerosis (n=36). Coronary stenosis vs. No coronary stenosis was evaluated on Serum apolipoprotein B level (mg/dl) (p=<0.05). Patients with coronary stenosis had significantly higher serum apolipoprotein B levels (121.5 vs 98.5 mg/dl, p<0.05) and lower HDL3 levels compared to those without stenosis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: