Key result
Plasma lipoprotein levels (total, LDL, and HDL cholesterol) were not significantly associated with angiographic coronary disease severity when adjusting for age.
Why the study?
Do serum lipoprotein levels correlate with angiographically defined coronary artery disease severity in men with suspected ischemic heart disease?
Cross-Sectional (n=43)
No
Do serum lipoprotein levels correlate with angiographically defined coronary artery disease severity in men with suspected ischemic heart disease?
In this small cohort of men with suspected ischemic heart disease, age, rather than serum lipoprotein levels, was the primary determinant of angiographic coronary artery disease severity.
Age adjustment may negate lipoprotein-CAD severity links in suspected IHD; leaves open independent lipid effects in broader or longitudinal cohorts.
The relationship of coronary artery disease to plasma lipoproteins was examined in 43 men admitted to our unit with suspected ischemic heart disease. Coronary arteriography was performed, and a score reflecting the severity of disease was assigned to the angiogram. Plasma, obtained after a 12-h overnight fast, was assayed for triglycerides, total cholesterol, high-density lipoprotein (HDL) cholesterol, and HDL-3 cholesterol. HDL-2 cholesterol was found by subtraction. The cholesterol contents of very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) were quantitated by the Freidwald equation. Men with high coronary scores tended to be older, and subjects with moderate coronary disease had significantly higher total and LDL cholesterol values than those with minimal disease. Age was the only factor to be significantly associated with coronary score and there was no significant association between coronary score and total LDL and HDL cholesterol or its subfractions when the age factor was taken into account.
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O’Sullivan et al. (1990) conducted a cross-sectional in suspected ischemic heart disease (n=43). Plasma lipoproteins was evaluated on Coronary score reflecting severity of disease on angiogram. Plasma lipoprotein levels (total, LDL, and HDL cholesterol) were not significantly associated with angiographic coronary disease severity when adjusting for age.
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