Key result
In adult males, HDL-cholesterol concentrations were significantly lower in patients with coronary heart disease compared to healthy subjects (38.5 vs 47.5 mg/dl, p<0.001), and the HDL-C/LDL-C ratio was inversely related to the angiographic severity of coronary artery sclerosis.
Cross-Sectional (n=142)
Absolute Event Rate: 38.5% vs 47.5%
p-value: p=<0.001
The HDL-C/LDL-C ratio is inversely correlated with the angiographic severity of coronary artery sclerosis, suggesting its utility as a marker for disease severity.
HDL-C/LDL-C ratio may mark CAD severity in men; leaves open whether it adds value beyond HDL-C or warrants prospective validation.
This study was undertaken to evaluate the relationship between serum lipoprotein concentration and angiographic severity of coronary artery sclerosis in adult male.HDL-, LDL-, and VLDL-cholesterol were measured in normal subjects (N=47, average age 44 y/o), non-coronary heart disease (Non-CHD, N=23, average age 38 y/o) and coronary heart disease (CHD, N=72, average age 52y/o) by means of heparin-CaCl and O-phthaladehyde method.All patients of Non CHD and CHD were studied by selective coronary cine-angiography. And as an index of severity of coronary artery sclerosis, coronary score of modified Friesinger method was applied to those who underwent selective coronary cine-angiography. The results were as follows:1) HDL-cholesterol concentrations of CHD group was 28.5±7.3mg/dl and apparently lower than that of normal subject (47.5±10.4mg/dl) or of Non-CHD group (45.4±6.5mg/dl). LDL-cholesterol concentrations of CHD group, normal subjects and Non-CHD group were 140.3±30.7mg/dl, 121.1±27.1mg/dl, 117.9±27.4mg/dl, respectively.2) No significant correlation was found between HDL-cholesterol and coronary score among CHD group. However HDL-C/LDL-C ratio was inversely related to severity of coronary artery disease.In CHD group, all patients with less than 2.50 of the ratio (HDL-C/LDL-C×10) showed severe coronary artery sclerosis more than coronary score 5, whereas no patients with the ratio of over 4.0 showed severe coronary artery sclerosis.
No takes yet. Share an insight, caveat, or question.
Wakiya et al. (1980) conducted a cross-sectional in Coronary Artery Sclerosis / Coronary Heart Disease (n=142). Serum lipoprotein concentration (HDL-C and HDL-C/LDL-C ratio) vs. Healthy subjects and non-CHD patients was evaluated on HDL-cholesterol concentration (p=<0.001). In adult males, HDL-cholesterol concentrations were significantly lower in patients with coronary heart disease compared to healthy subjects (38.5 vs 47.5 mg/dl, p<0.001), and the HDL-C/LDL-C ratio was inversely related to the angiographic severity of coronary artery sclerosis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: