Why the study?
Does free propranolol concentration correlate better with antagonism of isoproterenol tachycardia than total plasma concentration in normal and hypertensive subjects?
Population
16 subjects (8 normal subjects and 8 hypertensive patients)
Comparison
Chronic intravenous infusion of propranolol vs Normal subjects versus hypertensive patients
Design
Other
Authors
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Free propranolol levels may better predict beta-blockade than total concentrations; leaves open whether monitoring improves outcomes in hypertension.
Does free propranolol concentration correlate better with antagonism of isoproterenol tachycardia than total plasma concentration in normal and hypertensive subjects?
The effect of propranolol on heart rate is a predictable function of free drug concentration, indicating that individual variations in receptor sensitivity are minor compared to variations in bioavailability.
McDevitt et al. (1976) studied this question.
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