Why the study?
Does propranolol dose correlate with heart rate responses to physiological maneuvers and isoproterenol in human subjects?
Population
7 subjects
Comparison
Propranolol 10, 20, 40, 80, or 160 mg orally… vs Placebo
Design
Other
Follow-up
weekly basis
Authors
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Propranolol concentrations may best indicate beta blockade when exercise testing is unavailable; leaves open whether they should guide dosing over heart rate responses.
Does propranolol dose correlate with heart rate responses to physiological maneuvers and isoproterenol in human subjects?
Reduction in maximal exercise tachycardia correlates best with propranolol concentrations, but serum concentration remains the most reliable indicator of appropriate beta blockade therapy when exercise cannot be performed.
Hager et al. (1981) studied this question.
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