Why the study?
Does plasma propranolol concentration correlate with therapeutic response (exercise performance) in patients with angina pectoris?
Population
Patients with documented coronary artery disease and angina pectoris
Design
Cohort
Authors
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Supports targeting 64-98% beta-blockade for angina relief; leaves open whether plasma levels improve titration over clinical response.
Does plasma propranolol concentration correlate with therapeutic response (exercise performance) in patients with angina pectoris?
Maximum therapeutic response to propranolol in angina patients occurs at 64-98% of total beta-adrenergic blockade, corresponding to average doses of 144 mg/day and plasma concentrations of 30 ng/ml.
Pine et al. (1975) studied this question.
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