March 1, 2003Arteriosclerosis Thrombosis and Vascular Biology

GATA-6 Is Involved in PPARγ-Mediated Activation of Differentiated Phenotype in Human Vascular Smooth Muscle Cells

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Population

human vascular smooth muscle cells (VSMCs)

Design

Preclinical

Authors

MAMitsuru AbeKyoto Medical Center KHKoji HasegawaKanazawa University HWHiromichi WadaKyoto Medical Center

Discussion

Member takes

Implication

Supports PPARgamma-mediated VSMC differentiation via GATA-6; hypothesis-generating with no clinical translation yet.

Structured PICO

Population

human vascular smooth muscle cells (VSMCs)

Intervention

15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) and troglitazone (PPARgamma ligands)

Outcome

expression of smooth muscle myosin heavy chain and smooth muscle alpha-actin, and DNA binding activity of GATA-6surrogate

PPARgamma-dependent pathways induce a differentiated phenotype in proliferative human vascular smooth muscle cells partially through a GATA-6-dependent transcriptional mechanism.

Cite This Study

Abe et al. (2003) studied this question.

synapsesocial.com/papers/6a86c1e4ed1c9801b3cf7fde https://doi.org/10.1161/01.atv.0000059405.51042.a0

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Ask AI

Bookmark

GATA-6 Is Involved in PPARγ-Mediated Activation of Differentiated Phenotype in Human Vascular Smooth Muscle Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

GATA-6 Is Involved in PPARγ-Mediated Activation of Differentiated Phenotype in Human Vascular Smooth Muscle Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider