Population
Bovine pulmonary artery endothelial cells, rat epididymal fat pad endothelial cells, and bovine pulmonary…
Comparison
Exposure to varying oxygen tensions and… vs Normoxia (20% O2)
Design
Preclinical
Authors
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Should not alter clinical oxygen management; hypothesis-generating for transcriptional XD/XO regulation in endothelial hypoxia.
Oxygen tension regulates xanthine dehydrogenase/xanthine oxidase gene expression in endothelial cells primarily at the transcriptional level, with hypoxia increasing expression.
Hassoun et al. (1994) studied this question.
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