Key result
Diabetic peripheral neuropathy in patients with type 2 diabetes is associated with reduced functional connectivity between the lower limb sensorimotor cortex and brain regions involved in motion and motor control, including the right cerebellar lobule VI and anterior cingulate gyrus.
Why the study?
The mechanisms linking diabetic peripheral neuropathy with various brain function abnormalities in patients remained unclear.
Cross-Sectional (n=126)
No
p-value: p=<0.001
Diabetic peripheral neuropathy in patients with type 2 diabetes is associated with altered resting-state functional connectivity between the lower limb sensorimotor cortex and brain regions involved in motor control and cognition.
Background The mechanisms associated between diabetic peripheral neuropathy (DPN) and various brain function abnormalities in patients remains unclear. This study attempted to indirectly evaluate the effect of DPN on brain function in patients with type 2 diabetes mellitus (T2DM) by characterizing the resting-state functional connectivity (FC) of the lower limb sensorimotor cortex (LSM). Methods Forty-four T2DM patients with diabetic peripheral neuropathy (DPN), 39 T2DM patients without diabetic peripheral neuropathy (ND), and 43 healthy controls (HCs) underwent a neuropsychological assessment and resting-state functional magnetic resonance imaging examinations to examine the differences in FC between the LSM and the whole brain. The relationships of FC with clinical/cognitive variables were examined. Results In comparison with the HCs group, the ND group showed reduced FC of the LSM with the right lateral occipitotemporal cortex (LOTC) and increased FC with the medial superior frontal gyrus (SFGmed), while the DPN group showed reduced FC of the LSM with the right cerebellar lobule VI, the right LOTC, the rostral prefrontal cortex (rPFC), and the anterior cingulate gyrus (ACC). Moreover, in comparison with the ND group, the DPN group showed reduced FC of the LSM with the ACC, SFGmed, and rPFC. In the DPN group, the FC between the LSM and right cerebellar lobule VI was significantly correlated with fasting blood glucose levels (r = -0.490, p = 0.001), and that between the LSM and ACC was significantly correlated with the Montreal Cognitive Assessment score (r = 0.479, p = 0.001). Conclusions Patients with T2DM may show abnormal motion-related visual perceptual function before the appearance of DPN. Importantly, DPN can influence the brain regions that maintain motion and motor control, and this effect is not limited to motor function, which may be the central neuropathological basis for diabetic peripheral neuropathy.
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Zhang et al. (2024) conducted a cross-sectional in Type 2 diabetes mellitus with and without diabetic peripheral neuropathy (n=126). Diabetic peripheral neuropathy vs. Type 2 diabetes without neuropathy and healthy controls was evaluated on Resting-state functional connectivity between the lower limb sensorimotor cortex and the whole brain (p=<0.001). Diabetic peripheral neuropathy in patients with type 2 diabetes is associated with reduced functional connectivity between the lower limb sensorimotor cortex and brain regions involved in motion and motor control, including the right cerebellar lobule VI and anterior cingulate gyrus.
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