Key result
BPHx mice fed a western type diet for 16 weeks developed obesity, hypertension, hyperlipidaemia, and accelerated atherosclerosis, serving as a novel model for metabolic syndrome.
Why the study?
No animal model currently exists to study metabolic syndrome in the context of atherosclerosis.
Novel BPHx model aids preclinical metabolic syndrome research; leaves open human translation.
Metabolic Syndrome (MetS) is a complex and multifactorial condition often characterised by obesity, hypertension, hyperlipidaemia, insulin resistance, glucose intolerance and fasting hyperglycaemia. Collectively, MetS can increase the risk of atherosclerotic-cardiovascular disease, which is the leading cause of death worldwide. However, no animal model currently exists to study MetS in the context of atherosclerosis. In this study we developed a pre-clinical mouse model that recapitulates the spectrum of MetS features while developing atherosclerosis. When BPHx mice were placed on a western type diet for 16 weeks, all the classical characteristics of MetS were observed. Comprehensive metabolic analyses and atherosclerotic imaging revealed BPHx mice to be obese and hypertensive, with elevated total plasma cholesterol and triglyceride levels, that accelerated atherosclerosis. Altogether, we demonstrate that the BPHx mouse has all the major components of MetS, and accelerates the development of atherosclerosis.
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Dragoljevic et al. (2021) studied Metabolic Syndrome and atherosclerosis. Western type diet was evaluated on Development of metabolic syndrome features and atherosclerosis. BPHx mice fed a western type diet for 16 weeks developed obesity, hypertension, hyperlipidaemia, and accelerated atherosclerosis, serving as a novel model for metabolic syndrome.
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