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What are the acute haemodynamic effects of acetaldehyde in anaesthetized dogs?
What are the acute haemodynamic effects of acetaldehyde in anaesthetized dogs?
The acute cardiovascular effects of acetaldehyde are primarily mediated by the release of catecholamines from sympathetic nerve endings and the adrenal medulla.
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Acetaldehyde's effects are catecholamine-mediated in dogs; leaves open human translation and clinical relevance.
The acute haemodynamic effects of acetaldehyde were studied in anaesthetized dogs. Acetaldehyde increased heart rate, systemic arterial pressure, pulmonary arterial pressure, cardiac output, systemic venous return, and myocardial contractile force. Acetaldehyde constricts the peripheral vascular beds in the brachial, femoral, renal, and common carotid arteries and dilates those of the coronary, hepatic, and superior mesenteric arteries. Alpha- and beta-adrenergic blockade not only abolished the cardiovascular effects of acetaldehyde, but also reversed its pressor effect. It is concluded that most of the haemodynamic effects of acetaldehyde result from the release of catecholamines from sympathetic nerve endings and the adrenal medulla.
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McCloy et al. (1974) studied this question.
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