Why the study?
Does enhanced acetaldehyde exposure via cardiac-specific overexpression of alcohol dehydrogenase exacerbate cardiac contractile dysfunction after chronic ethanol ingestion in mice?
Population
ADH transgenic and wild-type FVB mice
Comparison
4% alcohol diet for 8 weeks vs Control diet for 8 weeks
Design
Preclinical
Follow-up
8 weeks
Authors
Loading...
Enhanced acetaldehyde exposure worsens ethanol cardiotoxicity in mice; hypothesis-generating and leaves open human relevance.
Does enhanced acetaldehyde exposure via cardiac-specific overexpression of alcohol dehydrogenase exacerbate cardiac contractile dysfunction after chronic ethanol ingestion in mice?
Increased cardiac acetaldehyde exposure exacerbates cardiac contractile dysfunction and oxidative damage after chronic alcohol intake in a mouse model.
Hintz et al. (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: