December 1, 2007Obesity

Interaction Between High‐Fat Diet and Alcohol Dehydrogenase on Ethanol‐Elicited Cardiac Depression in Murine Myocytes

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Population

Cardiomyocytes from alcohol dehydrogenase (ADH) transgenic and Friend Virus-B type (FVB) mice

Comparison

High-fat diet for 16 weeks combined with ethanol… vs Low-fat diet and non-ethanol treated controls

Design

Preclinical

Follow-up

16 weeks

Authors

Discussion

Hypothesis-generating for worsened ethanol cardiotoxicity in obesity; human studies required before any clinical relevance.

Population

Cardiomyocytes from alcohol dehydrogenase (ADH) transgenic and Friend Virus-B type (FVB) mice

Intervention

High-fat diet for 16 weeks combined with ethanol exposure

Comparator

Low-fat diet and non-ethanol treated controls

Outcome

Mechanical and intracellular Ca2+ properties (peak shortening, maximal velocity of shortening/relengthening, time-to-90% relengthening)surrogate

High-fat diet and ADH overexpression exacerbate ethanol-induced cardiac depression and cellular damage in murine models.

Jun Ren (2007) studied this question.

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