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June 1, 1993Journal of Cardiovascular Pharmacology

Frequency-Dependent Effects of Adenosine and Verapamil on Atrioventricular Conduction of Isolated Guinea Pig Hearts

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Why the study?

Does adenosine have more pronounced frequency-dependent effects on AV conduction than verapamil in isolated guinea pig hearts?

Population

Isolated guinea pig hearts perfused by the method of Langendorff

Comparison

Adenosine 3 microM vs Verapamil 0.01 microM

Design

Preclinical

Authors

FSFritz SterzComprehensive Cancer Center ViennaUSUlrike StarkUniversity of ViennaMBMaria BacherneggUniversity of Vienna

Discussion

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Implication

May support adenosine preference in AVNRT; leaves open translation from guinea pig model to human SVT therapy.

Structured PICO

Does adenosine have more pronounced frequency-dependent effects on AV conduction than verapamil in isolated guinea pig hearts?

P
Population
Isolated guinea pig hearts perfused by the method of Langendorff
I
Intervention
Adenosine 3 microM
C
Comparator
Verapamil 0.01 microM
O
Outcome
Time constant (tau) of drug-induced changes in AV conduction after abrupt shortening of basic cycle length from 240 to 180 mssurrogate

Adenosine has more pronounced frequency-dependent effects on AV conduction than verapamil, which may explain its higher clinical efficacy in supraventricular tachycardias involving the AV node.

Cite This Study

Sterz et al. (1993) studied this question.

synapsesocial.com/papers/6a86c8643a1d8ec5fdd3be07https://doi.org/10.1097/00005344-199306000-00016
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A comparison of the effects of adenosine and verapamil on the conduction and pacemaker system of isolated guinea pig hearts1993 · 4 citations
  2. 2The Frequency‐Dependent Effects of Verapamil on Antegrade Refractory Periods and Conduction in the Atrioventricular Node in Man1992 · 2 citations
  3. 3Frequency-dependent effects of verapamil on atrioventricular nodal conduction in man.1985 · 28 citations
  4. 4Effect of Verapamil on the Sinoatrial and Atrioventricular Nodes of the Rabbit and the Mechanism by Which it Arrests Reentrant Atrioventricular Nodal Tachycardia1974 · 284 citations
  5. 5Frequency-dependent effects of calcium antagonists on atrioventricular conduction and refractoriness: demonstration and characterization in anesthetized dogs.1986 · 58 citations