Why the study?
Does the synthesis of noradrenaline differ in patients with idiopathic orthostatic hypotension compared to normal subjects?
Population
3 patients with idiopathic orthostatic (postural) hypotension
Comparison
Infusion of 104.6 µc of 3-hydroxytyramine-2-14C… vs Normal subjects
Design
Case_series
Follow-up
5 days
Authors
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May indicate neurogenic defect in orthostatic hypotension; hypothesis-generating and should not yet change practice.
Does the synthesis of noradrenaline differ in patients with idiopathic orthostatic hypotension compared to normal subjects?
Idiopathic orthostatic hypotension is associated with a significant reduction in noradrenaline synthesis, suggesting a defect in neurogenic structures.
Goodall et al. (1968) studied this question.
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