October 1, 1967CirculationOpen Access

Noradrenaline Release and Metabolism in Orthostatic (Postural) Hypotension

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Population

15 hypotensive patients, including 7 classified as having idiopathic orthostatic (postural) hypotension.

Design

Case_series

Authors

MGMcC. GoodallUniversity of Birmingham WHW. R. HarlanUniversity of North Carolina at Chapel Hill HAHarold AltonUniversity of Cambridge

Discussion

Member takes

Implication

Indicates sympathetic neuronal deficit in idiopathic orthostatic hypotension; hypothesis-generating and should not yet change practice.

Structured PICO

Population

15 hypotensive patients, including 7 classified as having idiopathic orthostatic (postural) hypotension.

Outcome

Urinary output of noradrenaline and rate of metabolism of circulating noradrenalinesurrogate

Idiopathic orthostatic hypotension is associated with decreased noradrenaline output, likely due to an anatomic deficit in efferent sympathetic neurons.

Limitations

Results do not permit a definite conclusion that there is an anatomic deficit or decrease in efferent sympathetic neurons

Cite This Study

Goodall et al. (1967) studied this question.

synapsesocial.com/papers/6a7b68fbb008f0cadf32a197 https://doi.org/10.1161/01.cir.36.4.489

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