Pharmacology of Antagonists of Angiotensin I and II
Population
Rat uterus strips in vitro and anesthetized rats treated with phenoxybenzamine and propranolol, made acutely…
Design
Preclinical
Authors
Discussion
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Implication
Preclinical rat data should not change practice; leaves open translation of angiotensin analogues to human hypertension therapy.
Structured PICO
P
Population
Rat uterus strips in vitro and anesthetized rats treated with phenoxybenzamine and propranolol, made acutely hypertensive by unclamping a temporarily occluded renal pedicle.
I
Intervention
Infusion of octapeptide (8-Cys-AII, 8-Ile-AII, 4-Phe-8-Tyr-AII, p-fluoro-4-Phe-AII) and decapeptide (4-Phe-8-Tyr-AI, 8-Ile-AI) angiotensin analogues.
O
Outcome
Antagonism of angiotensin I and II, inhibition of angiotensin-converting enzyme, and reduction in blood pressure.surrogate
Decapeptide angiotensin analogues can function as ACE inhibitors and generate octapeptide antagonists in vivo, effectively lowering blood pressure in hypertensive rat models.
Cite This Study
Needleman et al. (1972) studied this question.