June 1, 1992British Journal of PharmacologyOpen Access

Evidence that the apparent complexity of receptor antagonism by angiotensin II analogues is due to a reversible and syntopic action

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Population

Rabbit isolated aorta assay, and guinea-pig aorta, ileum, and stomach

Design

Preclinical

Authors

YLY.J. LiuKing's College London NSNigel P. ShankleyJohnson & Johnson (Sweden)NWN J WelshSt Thomas' Hospital

Discussion

Member takes

Implication

Hypothesis-generating for insurmountable AT1 antagonism mechanisms; leaves open whether peptide analogues confer advantages in cardiovascular disease models.

Structured PICO

Population

Rabbit isolated aorta assay, and guinea-pig aorta, ileum, and stomach

Intervention

Angiotensin II (AII), two non-peptide antagonists (DuP 753 and IMI), and eight peptide analogues of AII

Outcome

Receptor antagonism characteristics (pKB values, concentration-effect curves)surrogate

The complex receptor antagonism profile of angiotensin II peptide analogues is due to a reversible and syntopic action at the AII receptor that causes a saturable reduction in agonist efficacy.

Cite This Study

Liu et al. (1992) studied this question.

synapsesocial.com/papers/6a1245c2ea48cb855a3480b9 https://doi.org/10.1111/j.1476-5381.1992.tb14322.x

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Implication

Hypothesis-generating for insurmountable AT1 antagonism mechanisms; leaves open whether peptide analogues confer advantages in cardiovascular disease models.

Evidence that the apparent complexity of receptor antagonism by angiotensin II analogues is due to a reversible and syntopic action

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Evidence that the apparent complexity of receptor antagonism by angiotensin II analogues is due to a reversible and syntopic action

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider