Why the study?
Does fludrocortisone administration increase plasma ANP levels during mineralocorticoid escape in healthy volunteers?
Does fludrocortisone administration increase plasma ANP levels during mineralocorticoid escape in healthy volunteers?
Plasma ANP levels rise significantly during mineralocorticoid administration, suggesting a hormonal role in overcoming sodium-retaining effects (mineralocorticoid escape).
ANP rise with fludrocortisone supports its role in mineralocorticoid escape; leaves open relevance to patients with hypertension or HF.
Plasma levels of atrial natriuretic peptide (ANP) were measured by radioimmunoassay in eight normal healthy volunteers before and during mineralocorticoid escape. Mean plasma ANP on a fixed sodium intake before fludrocortisone was 6.5 +/- SEM 1.1 pg/ml. Within 24 h of fludrocortisone administration there was a significant increase in plasma ANP which continued to increase daily reaching a plateau by day 4 (14.9 +/- 2.4 pg/ml) to day 7 (15.1 +/- 2.6 pg/ml). The rise in plasma ANP was closely related to the amount of sodium retained during the fludrocortisone treatment and the sodium 'escape' occurred by days 4 to 7. These results support the concept that ANP could play an important hormonal role in over-coming the sodium-retaining effects of mineralocorticoids in man.
No takes yet. Share an insight, caveat, or question.
Cappuccio et al. (1987) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: