Why the study?
Does hyperglycemia alter the renal hemodynamic response to ACE inhibition in healthy subjects?
Population
9 healthy subjects in high-salt balance
Comparison
Intravenous glucose administration to achieve… vs Absence of hyperglycemia (normoglycemic state)
Design
Other
Follow-up
Acute (during 90-minute infusion)
Authors
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May support cautious ACEI use in hyperglycemia; leaves open translation to diabetic or hypertensive kidney disease.
Does hyperglycemia alter the renal hemodynamic response to ACE inhibition in healthy subjects?
Hyperglycemia enhances renal vasodilation in response to ACE inhibition in healthy subjects, suggesting activation of the intrarenal renin-angiotensin system.
Osei et al. (1999) studied this question.