Key result
In patients receiving long-term amiodarone therapy, the development of hyperthyroidism significantly increased the recurrence of sustained ventricular tachycardia compared to the euthyroid period (31% vs 3%, p<0.01).
Why the study?
Does amiodarone-induced thyroid dysfunction increase the recurrence of ventricular tachyarrhythmias in patients receiving long-term amiodarone therapy?
Population
232 Japanese patients with life-threatening ventricular tachyarrhythmias and organic heart disease receiving…
Comparison
Long-term amiodarone therapy. vs Euthyroid period in the same patients, as well…
Design
Cohort
Follow-up
2 years
Authors
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Heightens need for thyroid monitoring on amiodarone; leaves open whether correcting hyperthyroidism prevents VT recurrence.
Cohort (n=232)
Does amiodarone-induced thyroid dysfunction increase the recurrence of ventricular tachyarrhythmias in patients receiving long-term amiodarone therapy?
Absolute Event Rate: 31% vs 3%
p-value: p=<0.01
Amiodarone-induced hyperthyroidism, but not hypothyroidism, significantly increases the risk of recurrent ventricular tachyarrhythmias, highlighting the need for careful arrhythmia monitoring when thyrotoxicosis develops.
Shiga et al. (2001) conducted a cohort in Ventricular tachyarrhythmias (VT/VF) with organic heart disease (n=232). Amiodarone-induced hyperthyroidism vs. Euthyroid period was evaluated on Recurrence of sustained ventricular tachycardia (p=<0.01). In patients receiving long-term amiodarone therapy, the development of hyperthyroidism significantly increased the recurrence of sustained ventricular tachycardia compared to the euthyroid period (31% vs 3%, p<0.01).
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