Key result
The ALOX5AP HapA haplotype was not significantly associated with stroke risk (OR 1.13; 95% CI 0.88-1.45).
Why the study?
Do ALOX5AP gene variants increase the risk of stroke?
Population
9,760 individuals (5,194 stroke cases and 4,566 controls) from genetic association studies
Comparison
ALOX5AP gene variants vs Controls without stroke
Design
Meta-analysis
Authors
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Does not support ALOX5AP HapA as a stroke risk factor; leaves open contributions from other variants or populations.
Meta-Analysis (n=9,760)
Do ALOX5AP gene variants increase the risk of stroke?
Odds Ratio: 1.13 (95% CI 0.88–1.45)
This meta-analysis found insufficient evidence to confirm a significant association between ALOX5AP gene variants and the risk of stroke.
Ζιντζαράς et al. (2009) conducted a meta-analysis in Stroke (n=9,760). ALOX5AP gene variants (HapA haplotype) vs. Controls was evaluated on Stroke risk (OR 1.13, 95% CI 0.88, 1.45). The ALOX5AP HapA haplotype was not significantly associated with stroke risk (OR 1.13; 95% CI 0.88-1.45).
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: