Key result
The ALOX5AP SG13S114 T allele was associated with a higher risk of ischemic stroke in the Iberian population (OR 1.22; 95% CI 1.06-1.40; P=0.006).
Why the study?
Does the ALOX5AP SG13S114 variant increase the risk of ischemic stroke in the Iberian population?
Population
1,092 ischemic stroke patients and 781 healthy controls from Spain and Portugal (Iberian population)
Comparison
T allele of the SG13S114 SNP in the ALOX5AP gene… vs Healthy controls (absence of the risk allele)
Design
Case-control
Authors
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Supports ALOX5AP variant research in Iberian stroke cohorts; leaves open clinical utility pending replication.
Case-Control (n=1,873)
Yes
Does the ALOX5AP SG13S114 variant increase the risk of ischemic stroke in the Iberian population?
Odds Ratio: 1.22 (95% CI 1.06–1.4)
p-value: p=0.006
The ALOX5AP SG13S114 variant is an independent risk factor for ischemic stroke in the Iberian population and is associated with increased ALOX5AP gene expression.
Domingues‐Montanari et al. (2010) conducted a case-control in Ischemic stroke (n=1,873). ALOX5AP SG13S114 T allele vs. Healthy controls was evaluated on Ischemic stroke (OR 1.22, 95% CI 1.06-1.40, p=0.006). The ALOX5AP SG13S114 T allele was associated with a higher risk of ischemic stroke in the Iberian population (OR 1.22; 95% CI 1.06-1.40; P=0.006).
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