January 1, 1968Proceedings of the National Academy of SciencesOpen Access

A human interferon that crosses the species line.

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Population

Human foreskin fibroblasts, human fetal fibroblasts, and rabbit kidney cell cultures

Comparison

Human interferon prepared by Newcastle disease… vs Control fluids, human leukocyte interferon, and…

Design

Preclinical

Authors

JDJan DesmyterUniversity College Dublin WRWilliam E. RawlsInstituto Conmemorativo Gorgas de Estudios de la Salud JMJ. L. MelnickBaylor College of Medicine

Discussion

Member takes

Implication

Suggests unexpected cross-species potency of human interferon; leaves open relevance to mammalian models or antiviral applications.

Structured PICO

Population

Human foreskin fibroblasts, human fetal fibroblasts, and rabbit kidney cell cultures

Intervention

Human interferon prepared by Newcastle disease virus (NDV) infection of human foreskin fibroblasts

Comparator

Control fluids, human leukocyte interferon, and rabbit interferon

Outcome

Reduction of vesicular stomatitis virus (VSV) plaque formationsurrogate

Human interferon produced in foreskin fibroblasts exhibits high interspecific antiviral activity in rabbit cells, demonstrating that some human interferons can cross species lines.

Cite This Study

Desmyter et al. (1968) studied this question.

synapsesocial.com/papers/6a86d666d25f83eb4715485e https://doi.org/10.1073/pnas.59.1.69

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A human interferon that crosses the species line.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A human interferon that crosses the species line.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider