Key result
The NOS3 T/C genotype frequency was significantly higher in pregnant women with preeclampsia (56%) and normal pregnancy (59%) compared to non-pregnant female donors (37%).
Why the study?
Do APOE, LPL, and NOS3 gene polymorphisms associate with the risk of preeclampsia in pregnant women or hypertension and metabolic syndrome in children?
Case-Control (n=888)
No
Do APOE, LPL, and NOS3 gene polymorphisms associate with the risk of preeclampsia in pregnant women or hypertension and metabolic syndrome in children?
Answers are grounded in this paper and cite their sources.
Polymorphisms in APOE, LPL, and NOS3 genes do not appear to be associated with the risk of hypertension or metabolic syndrome in children, though NOS3 heterozygosity may play a role in pregnancy.
Polymorphisms of APOE (E2/E3/E4), LPL (1595CG) and NOS3 (-786TC) in groups of pregnant women with and without preeclampsia, in donors, in children with hypertension, children with obesity and metabolic syndrome, and in control children were studied by PCR /RF LP analysis. Statistically significant increase of T/C genotype frequency of NOS3 in pregnant women with preeclampsia as well as in women with physiological pregnancy compared to this one in nonpregnant women of donors group was assessed (56%, 59% and 37%, respectively, F0.03).
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Glotov et al. (2011) conducted a case-control in Preeclampsia, arterial hypertension, metabolic syndrome (n=888). NOS3 (-786T>C), APOE, and LPL polymorphisms vs. Wild-type genotypes / Healthy controls was evaluated on Frequency of NOS3 T/C genotype (p=<0.03). The NOS3 T/C genotype frequency was significantly higher in pregnant women with preeclampsia (56%) and normal pregnancy (59%) compared to non-pregnant female donors (37%).
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