Key result
Adaptation of Foot-and-Mouth Disease Virus to guinea pigs did not attenuate its ability to cause acute, transmissible disease in pigs or lethal infection in suckling mice, despite altering its receptor recognition in cell culture.
Population
Male guinea pigs, 7-day-old Swiss mice, domestic pigs, and various cell lines.
Comparison
Infection with guinea pig-adapted foot-and-mouth… vs Mock infection (PBS) or parental FMDV C-S8c1.
Design
Preclinical
Follow-up
Up to 10 days post-infection for pigs, 9 days for mice
Authors
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Preserves FMDV virulence in pigs and mice despite cell-culture receptor change; leaves open receptor-independent pathogenesis in natural hosts.
Adaptation of FMDV to an unnatural host (guinea pig) alters receptor recognition in cell culture but preserves infectivity and pathogenesis in natural hosts (pigs) via integrin alphavbeta6.
Núñez et al. (2007) studied Foot-and-Mouth Disease Virus (FMDV) infection. Guinea pig-adapted FMDV vs. Wild-type FMDV (C-S8c1) or mock was evaluated on Infectivity and clinical signs of disease in natural hosts (pigs) and suckling mice. Adaptation of Foot-and-Mouth Disease Virus to guinea pigs did not attenuate its ability to cause acute, transmissible disease in pigs or lethal infection in suckling mice, despite altering its receptor recognition in cell culture.
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