Why the study?
Is cardiac amyloidosis associated with QT interval abnormalities and an increased incidence of ventricular arrhythmias compared to healthy controls?
Population
30 patients with systemic amyloidosis verified by biopsy and strong indications of cardiac amyloidosis, and…
Design
Case-control
Authors
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QTc prolongation in cardiac amyloidosis warrants no immediate arrhythmia concern; leaves open whether other repolarization metrics confer risk.
Is cardiac amyloidosis associated with QT interval abnormalities and an increased incidence of ventricular arrhythmias compared to healthy controls?
Despite having prolonged QTc and thickened cardiac walls, patients with cardiac amyloidosis do not exhibit increased QTc dispersion or a higher incidence of arrhythmias compared to healthy controls.
Parthenakis et al. (1996) studied this question.
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