Key result
Virus population bottlenecks during within-host progression and transmission are influenced by cellular-level bottlenecks, highlighting the importance of studying the multiplicity of cellular infection.
The study of the multiplicity of cellular infection (MOI) is central to understanding virus population bottlenecks during colonization and transmission.
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Cellular bottlenecks should inform viral transmission models; leaves open whether targeting multiplicity of infection alters progression or spread.
Gutiérrez et al. (2012) conducted a review in Viral infection. Virus population bottlenecks during within-host progression and transmission are influenced by cellular-level bottlenecks, highlighting the importance of studying the multiplicity of cellular infection.
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