Key result
A new statistical approach using de novo viral genetic variation confirmed the existence of extremely tight transmission bottlenecks for influenza A and SARS-CoV-2 viruses.
Why the study?
Current methods for estimating viral transmission bottleneck sizes rely only on polymorphic donor sites, which may substantially underestimate true bottleneck sizes.
A novel statistical approach using de novo viral genetic variation confirms extremely tight transmission bottlenecks for influenza A and SARS-CoV-2.
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Hypothesis-generating for respiratory virus dynamics; requires validation before informing clinical or public health decisions.
Shi et al. (2023) studied Influenza A and SARS-CoV-2 viral infections. Statistical approach using de novo viral genetic variation vs. Current approaches using polymorphic sites was evaluated on Transmission bottleneck size. A new statistical approach using de novo viral genetic variation confirmed the existence of extremely tight transmission bottlenecks for influenza A and SARS-CoV-2 viruses.
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