Key result
Myocytes from hibernating myocardium showed significantly reduced maximal isometric force compared to controls (11.6 vs 18.7 kN/m2, P<0.05) due to decreased myofibrillar protein density.
Absolute Event Rate: 11.6% vs 18.7%
p-value: p=<0.05
Decreased force development in hibernating myocardium is driven by a reduction in myofibrillar protein density and replacement by glycogen and mitochondria, rather than intrinsic myofilament dysfunction.
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Reduced myocyte force in hibernating myocardium is hypothesis-generating; human studies needed before clinical translation.
Bito et al. (2007) studied Hibernating myocardium (n=15). Hibernating myocardium vs. Control myocardium was evaluated on Maximal isometric force development (p=<0.05). Myocytes from hibernating myocardium showed significantly reduced maximal isometric force compared to controls (11.6 vs 18.7 kN/m2, P<0.05) due to decreased myofibrillar protein density.
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