Key result
Chronic reduction of coronary flow reserve in pigs increased myocyte apoptosis to 220 myocytes per 10^6 nuclei compared to 30 in sham-operated pigs (P<0.05).
Why the study?
Does chronic reversible ischemia induce myocyte apoptosis and regional myocyte loss in a porcine model of hibernating myocardium?
Population
Pigs instrumented with a stenosis of the left anterior descending coronary artery to chronically reduce…
Comparison
Chronic reduction of coronary flow reserve via… vs Sham-operated pigs.
Design
Preclinical
Follow-up
3 months
Authors
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May link chronic ischemia to myocyte loss in hibernating myocardium; leaves open its contribution to incomplete recovery after revascularization.
Does chronic reversible ischemia induce myocyte apoptosis and regional myocyte loss in a porcine model of hibernating myocardium?
Absolute Event Rate: 220% vs 30%
p-value: p=<0.05
Reversible ischemia in areas of chronically reduced coronary flow reserve induces regional myocyte loss via apoptosis, which may contribute to the progression to heart failure and explain incomplete functional recovery after revascularization.
Lim et al. (1999) studied Ischemic heart disease / hibernating myocardium. Stenosis of the left anterior descending coronary artery vs. Sham-operated pigs was evaluated on Myocyte apoptosis (myocytes per 10^6 myocyte nuclei) (p=<0.05). Chronic reduction of coronary flow reserve in pigs increased myocyte apoptosis to 220 myocytes per 10^6 nuclei compared to 30 in sham-operated pigs (P<0.05).
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