January 1, 2002Journal of Biological ChemistryOpen Access

Heparin Binding Stabilizes the Membrane-bound Form of Cobra Cardiotoxin

View Full Paper

Ask AI

Bookmark

Population

Cobra cardiotoxin (CTX) and lysophosphatidylcholine (LPC) micelles as a membrane model

Design

Preclinical

Authors

SSShih‐Che SueNational Tsing Hua University KCKun‐Yi ChienChang Gung University WHWeining HuangJiangnan University

Discussion

Member takes

Implication

May guide mechanistic research on toxin-membrane interactions; leaves open any clinical relevance for envenomation.

Structured PICO

Population

Cobra cardiotoxin (CTX) and lysophosphatidylcholine (LPC) micelles as a membrane model

Intervention

Heparin-derived hexasaccharide (Hep-6)

Outcome

Conformational changes of CTX near its membrane binding loops and binding activity toward LPCsurrogate

Heparin binding stabilizes the membrane-bound form of cobra cardiotoxin, demonstrating how hydrophilic carbohydrates can promote hydrophobic protein-lipid interactions.

Cite This Study

Sue et al. (2002) studied this question.

synapsesocial.com/papers/6a86e06636c36f97809ebe80 https://doi.org/10.1074/jbc.m104887200

View Full Paper

Ask AI

Bookmark

Heparin Binding Stabilizes the Membrane-bound Form of Cobra Cardiotoxin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Heparin Binding Stabilizes the Membrane-bound Form of Cobra Cardiotoxin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider