Key result
NMR analysis of the major P-type cardiotoxin CTX A3 revealed a single water molecule tightly hydrogen-bonded to Met26 within a dynamic, solvent-accessible loop.
Population
Taiwan cobra P-type cardiotoxin (CTX A3)
Design
Preclinical
Authors
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Should not change clinical practice; hypothesis-generating for water-mediated cardiotoxin-membrane interactions in animal models.
The exchange rate of the bound water in the dynamic loop II of P-type cardiotoxins may regulate their lipid binding mode near membrane surfaces.
Sue et al. (2001) studied this question. NMR analysis of CTX A3 was evaluated on Structure and dynamics of the water binding loop in CTX A3. NMR analysis of the major P-type cardiotoxin CTX A3 revealed a single water molecule tightly hydrogen-bonded to Met26 within a dynamic, solvent-accessible loop.
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