Key result
Treatment with anticoagulation and neurohormonal modulation led to complete recovery of left ventricular function and resolution of the apical thrombus at 3 months in a patient with Takotsubo cardiomyopathy and myasthenic crisis.
Why the study?
The concomitant occurrence of myasthenic crisis and Takotsubo cardiomyopathy with apical left ventricular thrombus had never been reported.
Case Report (n=1)
Electrocardiogram surveillance in patients with myasthenic crisis is essential to detect Takotsubo cardiomyopathy and its complications, such as left ventricular thrombus, which can be successfully treated with anticoagulation and neurohormonal therapy.
Hypothesis-generating for anticoagulation plus neurohormonal modulation in Takotsubo with thrombus; prospective trials needed before adoption.
BACKGROUND Myasthenia gravis can precipitate severe stress particularly during a myasthenic crisis episode. Takotsubo cardiomyopathy has been demonstrated in several conditions associated with emotional or physical stress. As a result, Takotsubo cardiomyopathy is not uncommon in patients with MG. The severe complications of Takotsubo cardiomyopathy include heart failure and left ventricular thrombus associated with thromboembolic risk. The concomitant myasthenic crisis and Takotsubo cardiomyopathy with apical left ventricular thrombus has never been reported. CASE REPORT A 67-year- old Thai female diagnosed with myasthenia gravis was admitted to the intensive care unit due to the myasthenic crisis. The 12-lead electrocardiogram showed marked QT interval prolongation and diffuse large T-wave inversion. Echocardiogram demonstrated basal hyperkinesia and apical akinesia with apical ballooning. Hyperechoic mass was noted in akinetic left ventricular apex. Takotsubo cardiomyopathy with apical left ventricular thrombus was diagnosed. Both conditions were successfully treated in this patient without any complications. CONCLUSIONS The electrocardiogram surveillance in patients with myasthenic crisis is essential to detect the occurrence of Takotsubo cardiomyopathy and its complications. Early diagnosis and treatments may decrease mortality and morbidity related with this condition.
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Pongbangli et al. (2019) conducted a case report in Takotsubo cardiomyopathy complicated with left ventricular thrombus in myasthenic crisis (n=1). Anticoagulant therapy and neurohormonal modulation was evaluated on Recovery of left ventricular function and resolution of thrombus. Treatment with anticoagulation and neurohormonal modulation led to complete recovery of left ventricular function and resolution of the apical thrombus at 3 months in a patient with Takotsubo cardiomyopathy and myasthenic crisis.
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