Key result
The CardioDetect rapid test for H-FABP demonstrated a sensitivity of 76.6% at admission and 94.4% at 2 hours for diagnosing early acute myocardial infarction, outperforming myoglobin and cTnI.
Why the study?
Does the CardioDetect H-FABP immunotest improve diagnostic performance for early acute myocardial infarction in patients presenting to the hospital?
Cross-Sectional (n=200)
Single-blind
No
Does the CardioDetect H-FABP immunotest improve diagnostic performance for early acute myocardial infarction in patients presenting to the hospital?
Absolute Event Rate: 76.6% vs 71%
The CardioDetect H-FABP immunotest, particularly when combined with cardiac troponin I, demonstrates high diagnostic accuracy for early acute myocardial infarction.
May aid early AMI diagnosis in observational cohorts; leaves open need for prospective validation before practice change.
Two hundreds patients suspected of acute myocardial infarction presenting to the hospital with a median symptom onset of 2.3 h (IQR 1.7-4.0 h) were enrolled in this study. The diagnostic performances of CardioDetect®, a one-step immunotest for heart-type fatty acid-binding protein (H-FABP), and its combination with cardiac troponin I (cTnI) at admission and 2 h after admission, were compared with different cardiac markers. The H-FABP immunotest had better sensitivities (76.6% and 94.4%) than the other cardiac markers and better specificities (88.2% and 81.7%) than myoglobin at admission and 2 h after admission. Both sensitivity and negative predictive value increased to over 90.0% at 2 h after admission. The areas under the receiver operator characteristic curve for the combination of H-FABP with cTnI were the greatest at admission [0.834 (95% CI: 0.774-0.894)].
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Liang et al. (2011) conducted a cross-sectional in Suspected early acute myocardial infarction (n=200). CardioDetect rapid test for H-FABP vs. Myoglobin and cardiac troponin I (cTnI) was evaluated on Sensitivity of H-FABP rapid test for diagnosis of AMI at admission (95% CI 67.5-84.3). The CardioDetect rapid test for H-FABP demonstrated a sensitivity of 76.6% at admission and 94.4% at 2 hours for diagnosing early acute myocardial infarction, outperforming myoglobin and cTnI.
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